The Chicago Cubs welcome the Milwaukee Brewers to Wrigley Field on Wednesday, September 2, for a 7:40 PM ET first pitch. David Peterson gets the ball for Chicago against Milwaukee's Jacob Misiorowski in what shapes up as a pivotal NL Central division matchup with September baseball in full swing. The Cubs are sending out a lineup loaded with recognizable names, and the Friendly Confines will be rocking for this one. These two clubs know each other well, and every game between them carries real weight at this stage of the regular season.

Cubs vs. Brewers Starting Pitchers: Peterson vs. Misiorowski

David Peterson draws the start for the Cubs. A left-handed starter with big-league experience, Peterson will need to navigate a Brewers lineup that can do damage in a variety of ways. His ability to command the strike zone and work through a lineup multiple times will be the central question of this outing.

Jacob Misiorowski takes the hill for Milwaukee. The right-hander is one of the more intriguing young arms the Brewers have developed, with a fastball-heavy approach that can be electric. He has the stuff to keep Cubs hitters off-balance, so Chicago's lineup will need to be disciplined early and look to make him work deep into counts.

Cubs Starting Lineup Against Milwaukee

• 1. Pete Crow-Armstrong, CF
• 2. Seiya Suzuki, DH
• 3. Alex Bregman, 3B
• 4. Michael Busch, 1B
• 5. Nico Hoerner, SS
• 6. Ian Happ, LF
• 7. Matt Shaw, 2B
• 8. Tyrone Taylor, RF
• 9. Miguel Amaya, C

Three Keys to Watch in Wednesday's Game

1. Pete Crow-Armstrong Setting the Table

PCA leading off at Wrigley is must-watch baseball. His ability to get on base and use his legs changes the entire complexion of an inning before the middle of the order even steps in. If he can be disruptive at the top, Suzuki and Bregman get better pitches to hit.

2. Alex Bregman in the Heart of the Order

Hitting third, Bregman is the kind of professional hitter who makes pitchers pay for any lapse in command. His approach at the plate — working counts, staying through the ball — puts pressure on Misiorowski from the jump. How the young Brewers starter handles Bregman will tell you a lot about how his night goes.

3. Peterson's Ability to Strand Runners

September baseball means lineups are set and the margins are thin. Peterson's effectiveness in high-leverage spots — runners on base, two outs, the game on the line — will likely determine whether the Cubs bullpen gets taxed or gets a breather heading into a deep stretch of the schedule.

Prediction: Cubs Win at Wrigley

This is a home game that matters, and the Cubs lineup has the depth to put crooked numbers on the board against a young pitcher still finding his footing at this level. Peterson keeps it competitive, the Wrigley crowd provides a lift, and Chicago takes care of business on Wednesday night. Cubs 4, Brewers 2.

Catch the game on Marquee Sports Network or MLB Network, with radio coverage on 104.3 The Score.